HDL (High-Density Lipoprotein) Remodeling and Magnetic Resonance Imaging-Assessed Atherosclerotic Plaque Burden: Study in a Preclinical Experimental Model
| Autor: | Ben-Aicha S., Casaní L., Muñoz-Garciá N., Joan-Babot O., Peña E., Aržanauskaite M., Gutierrez M., Mendieta G., Padró T., Badimon L., Vilahur G. |
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| Rok vydání: | 2020 |
| Předmět: |
Male
diagnostic imaging Leporidae Hypercholesterolemia Aortic Diseases abdominal aorta complication atherosclerotic plaque high density lipoprotein cholesterol blood Animals animal Aorta Abdominal nuclear magnetic resonance imaging Infusions Intravenous disease model Anticholesteremic Agents drug effect Cholesterol HDL hypocholesterolemic agent biological marker aortic disease Atherosclerosis Magnetic Resonance Imaging Plaque Atherosclerotic intravenous drug administration Disease Models Animal disease exacerbation Disease Progression Rabbits metabolism Biomarkers |
| Zdroj: | ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 1079-5642 |
| Popis: | Objective: HDL (high-density lipoprotein) role in atherosclerosis is controversial. Clinical trials with CETP (cholesterylester transfer protein)-inhibitors have not provided benefit. We have shown that HDL remodeling in hypercholesterolemia reduces HDL cardioprotective potential. We aimed to assess whether hypercholesterolemia affects HDL-induced atherosclerotic plaque regression. Approach and Results: Atherosclerosis was induced in New Zealand White rabbits for 3-months by combining a high-fat-diet and double-balloon aortic denudation. Then, animals underwent magnetic resonance imaging (basal plaque) and randomized to receive 4 IV infusions (1 infusion/wk) of HDL isolated from normocholesterolemic (NC-HDL; 75 mg/kg; n=10), hypercholesterolemic (HC-HDL; 75 mg/Kg; n=10), or vehicle (n=10) rabbits. Then, animals underwent a second magnetic resonance imaging (end plaque). Blood, aorta, and liver samples were obtained for analyses. Follow-up magnetic resonance imaging revealed that NC-HDL administration regressed atherosclerotic lesions by 4.3%, whereas, conversely, the administration of HC-HDLs induced a further 6.5% progression (P |
| Databáze: | OpenAIRE |
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