Prediabetes is independently associated with subclinical carotid atherosclerosis: An observational study in a non-urban mediterranean population
| Autor: | Vilanova M.B., Franch-Nadal J., Falguera M., Marsal J.R., Canivell S., Rubinat E., Miró N., Molló À., Mata-Cases M., Gratacòs M., Castelblanco E., Mauricio D. |
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| Rok vydání: | 2020 |
| Předmět: |
leukocyte count
obesity systolic blood pressure hypertension estimated glomerular filtration rate carotid intima-media thickness glucose tolerance alanine aminotransferase carotid atherosclerosis prevalence tobacco Article low density lipoprotein cholesterol disease burden male high density lipoprotein cholesterol human glucose kidney function hemoglobin A1c adult dyslipidemia creatinine diastolic blood pressure echography arterial wall thickness waist circumference major clinical study female impaired glucose tolerance risk factor diabetes mellitus observational study coronary artery disease prospective study uric acid blood level |
| Zdroj: | Journal of Clinical Medicine r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 2077-0383 |
| Popis: | This was a prospective, observational study to compare the burden of subclinical atherosclerosis as measured by carotid ultrasonography in a cohort of subjects with prediabetes vs. subjects with normal glucose tolerance (NGT) from a non-urban Mediterranean population. Atherosclerosis was assessed through carotid intima-media thickness (c-IMT), the presence/absence of carotid plaques, and plaque number. Among 550 subjects included, 224 (40.7%) had prediabetes. The mean c-IMT and the prevalence of carotid plaque were significantly higher in the prediabetes group compared to the NGT group (0.72 vs. 0.67 mm, p < 0.001; and 37.9% vs. 19.6%; p < 0.001, respectively). Older age, male gender, and increased systolic blood pressure were positively correlated with c-IMT and were independent predictors of the presence of plaques. In contrast, prediabetes and low-density lipoprotein (LDL)-c were predictors of the presence of plaque (odds ratio [OR] = 1.64; 95% confidence interval [CI] = 1.05–2.57; p = 0.03 and OR = 1.01; 95% CI = 1.00–1.02; p = 0.006, respectively) together with tobacco exposure and the leukocyte count (OR = 1.77; 95% CI = 1.08–2.89; p = 0.023 and OR = 1.20; 95% CI = 1.05–1.38; p = 0.008, respectively). In a non-urban Mediterranean population, prediabetes was associated with established subclinical carotid atherosclerosis. These findings could have implications for the prevention and treatment of CV risk in these subjects before the first symptoms of cardiovascular disease appear. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
| Databáze: | OpenAIRE |
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