Transplant Oncology in Primary and Metastatic Liver Tumor: Principles, Evidence and Opportunities
| Autor: | Sapisochin G, Hibi T, Toso C, Man K, Berenguer M, Heimbach J, Greten TF, Pugh TJ, Dawson LA, Mazzaferro V |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | ANNALS OF SURGERY r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| ISSN: | 0003-4932 |
| Popis: | Transplant oncology defines any application of transplant medicine and surgery aimed at improving cancer patients' survival and/or quality of life. In practice, liver transplantation for selected hepato-biliary cancers is the only solid organ transplant with demonstrated efficacy in curing cancer. Four are the proposed future contributions of transplant oncology in hepato-biliary cancer (4-e). 1. evolutionary approach to cancer care that includes liver transplantation; 2. elucidation of self and non-self recognition systems, by linking tumor and transplant immunology; 3. exploration of innovative endpoints both in clinical and experimental settings taking advantage from the access to the entire liver explant; 4. extension of surgical limitation in the multidisciplinary approach to hepato-biliary oncology. The aim of this review is to define the principles of transplant oncology that may be applied to hepato-biliary cancer treatment and research, attempting to balance current evidences with future opportunities. |
| Databáze: | OpenAIRE |
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