Use of newer prognostic indices for patients with myelodysplastic syndromes in the low and intermediate-1 risk categories: a population-based study
| Autor: | Valcarcel, D, Sanz, G, Ortega, M, Nomdedeu, B, Luno, E, Diez-Campelo, M, Ardanaz, MT, Pedro, C, Montoro, J, Collado, R, Andreu, R, Marco, V, Cedena, MT, de Paz, R, Tormo, M, Xicoy, B, Ramos, F, Bargay, J, Gonzalez, B, Brunet, S, Munoz, JA, Gomez, V, Bailen, A, Sanchez, J, Merchan, B, del Canizo, C, Vallespii T, Grp Espanol Sindromes Mielodisplas |
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| Rok vydání: | 2015 |
| Zdroj: | LANCET HAEMATOLOGY r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| ISSN: | 2352-3026 |
| Popis: | Background We aimed to compare the ability of recently developed prognostic indices for myelodysplastic syndromes to identify patients with poor prognoses within the lower-risk (low and intermediate-1) categories defined by the International Prognosis Scoring System (IPSS). Methods We included patients with de-novo myelodysplastic syndromes diagnosed between Nov 29, 1972, and Dec 15, 2011, who had low or intermediate-1 IPSS scores and were in the Spanish Registry of Myelodysplastic Syndromes. We reclassified these patients with the new prognostic indices (revised IPSS [IPSS-R], revised WHO-based Prognostic Scoring System [WPSS-R], Lower Risk Scoring System [LRSS], and the Grupo Espanol de Sindromes Mielodisplasicos [Spanish Group of Myelodysplastic Syndromes; GESMD]) and calculated the overall survival of the different risk groups within each prognostic index to identify the groups of patients with overall poor prognoses (defined as an expected overall survival < 30 months). We calculated overall survival with the Kaplan-Meier method. Findings We identified 2373 patients. None of the prognostic indices could be used to identify a population with poor prognoses (median overall survival |
| Databáze: | OpenAIRE |
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