A new clinical and immuno-virological score for predicting the risk of late severe infection in solid organ transplant recipients: the CLIV Score
| Autor: | San-Juan R, Fernandez-Ruiz M, Ruiz-Ruigomez M, Lopez-Medrano F, Ruiz-Merlo T, Andres A, Loinaz C, Len O, Azancot M, Montejo M, Rodriguez-Alvarez R, Fortun J, Escudero-Sanchez R, Gimenez E, Lora D, Albert E, Navarro D, Aguado J, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016) |
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| Rok vydání: | 2020 |
| Zdroj: | The Journal of infectious diseases r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname |
| ISSN: | 0022-1899 |
| Popis: | BACKGROUND: We aimed at constructing a composite score based on EBVd and simple clinical and immunological parameters to predict late severe infection (LI) beyond month 6 in SOT recipients.; METHODS: Kidney and liver transplant recipients between May 2014-August 2016 at four participating centers were included. Serum immunoglobulins and complement factors, peripheral blood lymphocyte subpopulations, and whole-blood EBVd were determined at months 1, 3 and 6. Cox regression analyses were performed to generate a weighted score for the prediction of LI.; RESULTS: Overall, 309 SOT recipients were followed-up for a median of 1,000 days from transplant (IQR: 822-1124). LI occurred in 104 patients (33.6%). The CLIV score consisted of the following variables at month 6: high-level EBVd (>1,500 IU/ml) and recurrent infection during the previous months (6 points); recipient age =70 years and chronic graft dysfunction (5 points); CMV mismatch (4 points); and CD8+ T-cell count |
| Databáze: | OpenAIRE |
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