Role of Haptoglobin as a Marker of Muscular Improvement in Patients with Multiple Sclerosis after Administration of Epigallocatechin Gallate and Increase of Beta-Hydroxybutyrate in the Blood: A Pilot Study
| Autor: | Orti J, Platero J, Benlloch M, Franco-Martinez L, Tvarijonaviciute A, Escriba-Alepuz J, Sancho-Castillo S |
|---|---|
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Biomolecules r-FISABIO. Repositorio Institucional de Producción Científica instname |
| ISSN: | 2218-273X |
| Popis: | Here, we report on the role of haptoglobin (Hp), whose expression depends on the synthesis of interleukin 6 (IL-6), related to the pathogenesis of multiple sclerosis (MS), as a possible marker of muscle improvement achieved after treatment with the polyphenol epigallocatechin gallate (EGCG) and an increase in the ketone body beta-hydroxybutyrate (BHB) in the blood. After 4 months of intervention with 27 MS patients, we observed that Hp does not significantly increase, alongside a significant decrease in IL-6 and a significant increase in muscle percentage. At the same time, Hp synthesis is considerably and positively correlated with IL-6 both before and after treatment; while this correlation occurs significantly reversed with muscle percentage before treatment, no correlation is evident after the intervention. These results seem to indicate that Hp could be a marker of muscle status and could be a diagnosis tool after therapeutic intervention in MS patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|