Non-myeloablative hematopoietic stem cell transplantation in the treatment of severe idiopathic CD4+lymphocytopenia

Autor: Cervera, C, Fernandez-Aviles, F, de la Calle-Martin, O, Bosch, X, Rovira, M, Plana, M, Moreno, A, Garcia, F, Miro, JM, Martinez, A, Gallart, T, Carreras, E, Blade, J, Gatell, JM
Rok vydání: 2011
Předmět:
Zdroj: EUROPEAN JOURNAL OF HAEMATOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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ISSN: 0902-4441
Popis: A 40-year-old man with severe chronic idiopathic CD4+ lymphocytopenia complicated with opportunistic infections was successfully treated with non-myeloablative allogeneic hematopoietic stem cell transplantation. After conditioning with fludarabine plus low dose of total-body irradiation, CD34+ peripheral blood stem cells obtained by leukapheresis from his HLA-identical sister were infused. T cell and myeloid complete chimerism was achieved at day +28 and remained stable during the follow-up period. The patient did not develop infectious complications during the procedure. At 35 months of follow-up, his CD4+ T cell count was 1019 cells per microliter. Non-myeloablative allogeneic hematopoietic stem cell transplantation should be considered a treatment option for patients with severe forms of idiopathic CD4+ lymphocytopenia.
Databáze: OpenAIRE
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