Registry of the Spanish Network for Systemic Sclerosis Survival, Prognostic Factors, and Causes of Death
| Autor: | Simeon-Aznar, CP, Fonollosa-Pla, V, Tolosa-Vilella, C, Espinosa-Garriga, G, Campillo-Grau, M, Ramos-Casals, M, Garcia-Hernandez, FJ, Castillo-Palma, MJ, Sanchez-Roman, J, Callejas-Rubio, JL, Ortego-Centeno, N, Egurbide-Arberas, MV, Trapiellla-Martinez, L, Caminal-Montero, L, Saez-Comet, L, Velilla-Marco, J, Camps-Garcia, MT, de Ramon-Garrido, E, Esteban-Marcos, EM, Pallares-Ferreres, L, Navarrete-Navarrete, N, Vargas-Hitos, JA, de la Torre, RG, Salvador-Cervello, G, Rios-Blanco, JJ, Vilardell-Tarres, M, Spanish Soc Internal Med SEMI |
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| Rok vydání: | 2015 |
| Zdroj: | Medicine r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| ISSN: | 0025-7974 |
| Popis: | Systemic sclerosis (SSc) is a rare, multisystem disease showing a large individual variability in disease progression and prognosis. In the present study, we assess survival, causes of death, and risk factors of mortality in a large series of Spanish SSc patients. Consecutive SSc patients fulfilling criteria of the classification by LeRoy were recruited in the survey. Kaplan-Meier and Cox proportional-hazards models were used to analyze survival and to identify predictors of mortality. Among 879 consecutive patients, 138 (15.7%) deaths were registered. Seventy-six out of 138 (55%) deceased patients were due to causes attributed to SSc, and pulmonary hypertension (PH) was the leading cause in 23 (16.6%) patients. Survival rates were 96%, 93%, 83%, and 73% at 5, 10, 20, and 30 years after the first symptom, respectively. Survival rates for diffuse cutaneous SSc (dcSSc) and limited cutaneous SSc were 91%, 86%, 64%, and 39%; and 97%, 95%, 85%, and 81% at 5, 10, 20, and 30 years, respectively (log-rank: 67.63, P |
| Databáze: | OpenAIRE |
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