sFlt-1/PlGF for prediction of early-onset pre-eclampsia: STEPS (Study of Early Pre-eclampsia in Spain)

Autor: Perales, A, Delgado, JL, De la Calle, M, Garcia-Hernandez, JA, Escudero, AI, Campillos, JM, Sarabia, MD, Laiz, B, Duque, M, Navarro, M, Calmarza, P, Hund, M, Alvarez, FV, STEPS investigators
Rok vydání: 2017
Předmět:
Zdroj: ULTRASOUND IN OBSTETRICS & GYNECOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
ISSN: 0960-7692
Popis: Objective A high ratio of soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) has been linked to pre-eclampsia (PE). We evaluated the sFlt-1/PlGF ratio as a predictive marker for early-onset PE in women at risk of PE. Methods This prospective, Spanish, multicenter study included pregnant women with a risk factor for PE, including intrauterine growth restriction, PE, eclampsia or hemolysis, elevated liver enzymes and low platelet count syndrome in previous pregnancy, pregestational diabetes or abnormal uterine artery Doppler. The primary objective was to show that the sFlt-1/PlGF ratio at 20, 24 and 28 weeks' gestation was predictive of early-onset PE (
Databáze: OpenAIRE
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