Bioactive or Drug Eluting Stents in 75 years or older patients: The BIODES-75 Registry

Autor: Cordoba-Soriano J, Gutierrez-Diez A, Del Blanco B, Nunez J, Amat-Santos I, Oteo J, Romaguera R, Gallardo-Lopez A, Lozano Ruiz-Poveda F, Baello P, Aguar P, Jerez-Valero M, Jimenez-Diaz V, Serra B, Cascon J, Morales-Ponce F, Portero-Portaz J, Melehi El Assali D, Cerrato-Garcia P, Jimenez-Mazuecos J
Rok vydání: 2022
Zdroj: Cardiovascular revascularization medicine : including molecular interventions
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
Banco de España
ISSN: 1553-8389
Popis: BACKGROUND: TiNO-coated BAS have demonstrated competitive outcomes compared to drug-eluting stents (DES). These devices allow short antiplatelet regimens and may be a good option for the growing elderly population undergoing percutaneous coronary intervention (PCI).; METHODS: Multicenter observational trial in routine clinical practice. A propensity-score matched analysis compared a prospective cohort of patients = 75 years undergoing PCI with BAS, with a contemporary and retrospective cohort treated with last-generation DES. The co-primary endpoints of the study were the Target-Lesion-Failure (Cardiac death, non-fatal myocardial infarction, or target lesion revascularization) and Major Adverse Cardiovascular Events (total death, non-fatal myocardial infarction, stroke, or new revascularization) at 1 year.; RESULTS: Whole population included 1000 patients, and 326 patients in each group were matched for analysis. No differences in primary endpoints were found: TLF 10.4% vs. 11% (HR 0.96 (Confidence Interval 95%, 0.36-1.7; p = 0.87)) and MACE 16.3% vs. 17.2% (HR 0.98 (Confidence Interval 95%; 0.3-1.5, p = 0.93)). Patients treated with BAS received shorter antiplatelets regimens (dual antiplatelet therapy at 1 year, 25.7% vs. 70.6%, p = 0.0001), and they presented lower incidence of bleeding (3.7% vs. 11.7%, HR 0.3 (IC 95% 0.16-0.6, p = 0.001)).; CONCLUSION: In this real-life registry of patients = 75 years, BAS were similar to the latest-generation DES in terms of efficacy and reduced the duration of the antithrombotic therapy, lowering bleeding events. Copyright © 2022 Elsevier Inc. All rights reserved.
Databáze: OpenAIRE
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