Running title: Kinase inhibitors for ALS therapy
| Autor: | Palomo, Valle, Nozal, Vanesa, Rojas-Prats, Elisa, Gil, Carmen, Martínez, Ana |
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| Přispěvatelé: | Comunidad de Madrid, La Caixa, Ministerio de Educación, Cultura y Deporte (España), Instituto de Salud Carlos III, European Commission, Palomo, Valle [0000-0002-1473-4086], Nozal, V. [0000-0001-5260-5683], Gil, Carmen [0000-0002-3882-6081], Martínez, Ana [0000-0002-2707-8110] |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | 46 p.-3 fig.-2 tab. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that causes the progressive loss of motoneurons and, unfortunately, there is no effective treatment for this disease. Interconnecting multiple pathological mechanisms are involved in the neuropathology of this disease, including abnormal aggregation of proteins, neuroinflammation and dysregulation of the ubiquitin proteasome system. Such complex mechanisms, together with the lack of reliable animal models of the disease have hampered the development of drugs for this disease. Protein kinases, a key pharmacological target in several diseases, have been linked to ALS as they play a central role in the pathology of many diseases. Therefore several inhibitors are being currently trailed for clinical proof of concept in ALS patients. In this review, we examine the recent literature on protein kinase inhibitors currently in pharmaceutical development for this diseaseas future therapy for AS together with their involvement in the pathobiology of ALS. Comunidad de Madrid, Grant/Award Number:B2017/BMD3813; La Caixa Banking Foundation, Grant/Award Number:LCF/BQ/PR18/11640007; MECD, Grant/Award Numbers: FPU14-00204,FPU16/04466; ISCiii, Grant/Award Number:CIBERNED, CB18/05/00040; FEDER |
| Databáze: | OpenAIRE |
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