SARS-CoV-2-reactive antibody detection after SARS-CoV-2 vaccination in hematopoietic stem cell transplant recipients: Prospective survey from the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH-TC)

Autor: Piñana JL, López-Corral L, Martino R, Montoro J, Vazquez L, Pérez A, Martin-Martin G, Facal-Malvar A, Ferrer E, Pascual MJ, Sanz-Linares G, Gago B, Sanchez-Salinas A, Villalon L, Conesa-Garcia V, Olave MT, López-Jimenez J, Marcos-Corrales S, García-Blázquez M, Garcia-Gutiérrez V, Hernández-Rivas JÁ, Saus A, Espigado I, Alonso C, Hernani R, Solano C, Ferrer-Lores B, Guerreiro M, Ruiz-García M, Muñoz-Bellido JL, Navarro D, Cedillo A, Sureda A
Rok vydání: 2021
Předmět:
Zdroj: AMERICAN JOURNAL OF HEMATOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
ISSN: 0361-8609
Popis: This is a multicenter prospective observational study which included a large cohort (n = 397) of allogeneic (allo-HSCT) (n = 311) and autologous (ASCT) hematopoietic stem cell transplant (n = 86) recipients who were monitored for antibody detection within 3 to 6 weeks after complete SARS-CoV-2 vaccination from February 1st 2021 to July 20th 2021. Most patients (n = 387, 97.4%) received mRNA-based vaccines. Most of recipients (93%) were vaccinated more than 1 year after transplant. Detectable SARS-CoV-2-reactive antibodies were observed in 242 (78%) of allo-HSCT and in 73 (85%) of ASCT recipients. Multivariate analysis in allo-HSCT recipients identified lymphopenia
Databáze: OpenAIRE
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