| Autor: |
Aderibigbe, AO, Iwalewa, EO, Adesina, SK, Ukponmwan, OE, Adebanjo, AO |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Discovery and Innovation; Vol 19 (2007) |
| ISSN: |
1015-079X |
| Popis: |
The neuropharmacological effects of Aridanin Ð an N-acetylated glycoside isolated from Tetrapleura tetraptera fruit was examined for locomotory, exploratory, stereotyped behaviours and hexobarbitone-induced sleeping time (HIST) in mice. Aridanin (15- and 30 mg/kg i.p) produced a dose-dependent inhibition of novelty-induced rearing, grooming, body scratching and exploratory behaviour. It also potentiated the hexobarbitone-induced sleeping time (HIST), but did not change the stereotyped behaviour induced by apomorphine. These effects of aridanin suggest that it has a strong central depressant action which may be sedative in nature but lack psychopharmacological activities Keywords: Aridanin; central activities, sedation, Tetrapleura tetraptera fruitDiscovery and Innovation Vol. 19 (3) 2007: pp. 177-181 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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