Pattern of serum zinc level, peripheral blood lymphocyte and neutrophil counts among patients with sickle cell disease
| Autor: | Abdullahi, B.A., Saidu, H., Rogo, L.D., Ibrahim, A., Abdullahi, H.L., Jobbi, Y.D., Saleh, A.M., Saeed, S.A., Saidu, A. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Bayero Journal of Medical Laboratory Science; Vol. 5 No. 2 (2020); 230-235 |
| ISSN: | 2545-5672 2635-3792 |
| Popis: | Background: Zinc is an important mineral element serving as a cofactor in a number of cellular pathways including those involved in cell growth and proliferation. Sickle cell disease (SCD) is associated with excessive haemolysis and defective kidney function with consequential decrease in body’s pool of vital micronutrients. The abnormal loss of zinc in SCD may affect leucopoiesis. Aim: This study was aimed to determine the relationship between serum zinc and leukocyte subsets (Lymphocyte, neutrophil) in adult patients with SCD in steady state together with their counterpart apparently healthy controls. Materials and Methods: Blood samples were collected from 33 adult participants with SCD and 33 apparently healthy controls. Lymphocytes and Neutrophils counts were performed using automated haematology analyser (Sysmex KX21N) and serum Zinc level was determined spectrophometrically using the Br-PADAP method. Results: The results shows statistically significant difference in absolute lymphocyte and neutrophil counts for the two groups were P < 0.0001 and P < 0.0001, respectively. The serum zinc level was also statistically significant between the groups: P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|