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Objective: The study established the trends, changes and differences of interferon-gamma (IFN-λ) during pregnancy among HIV-infected and uninfected women in western Kenya.Design: A prospective study design.Setting: Academic Model Providing Accessible Treatment, and Health (AMPATH) which is associated with Moi Teaching and Referral Hospital (MTRH) in Western Kenya.Study participants: The study involved 44 HIV-infected pregnant women, who were asymptomatic and antiretroviral-naïve and 44 healthy pregnant women as controls.Results: A decreasing trend of IFN-λ was observed as pregnancy advanced in both groups. Among the HIV-infected, the change of IFN-λ at the second and third trimesters from first trimester were negative and significant, That is, [-2.0 (95% CI: -2.7, -1.2) pg/ml; P |
