| Autor: |
Eteng, MU, Ibekwe, HA, Essien, AD, Onyeama, HP |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Bio-Research; Vol 6, No 2 (2008); 264-366 |
| ISSN: |
1596-7409 |
| Popis: |
This study was designed to evaluate the efficacy (or otherwise) of Cataranthus roseus extract in ameliorating electrolyte imbalance following treatment with anti-diabetic drug chlorpropamide (Diabinese)R. A total of 32 rats of mixed sexes were randomly assigned into 4 treatment groups of 8 rats each. Group A (control) received placebo (0.14ml of 30% ethanol)/ kg body weight of rat. Group B received Diabinese in a dose of 1.6mg/kg body weight of rat while group C received 400mg /kg body weight of Cataranthus roseus (C. roseus) extract. Group D received Diabinese in a dose of 1.6mg/kg body weight plus 400mg/kg body weight C. roseus extract. The above dosages were administered twice daily via orogastric intubation in a 12 hour cycle. The administration was terminated at the end of 14 days, animal sacrificed, serum collected and electrolyte (Na+, K+ and CL-) profile assayed. The result obtained showed no-significant (P>0.05) decrease in serum concentration of chloride ion in Group B-D relative to control. There is however, a significant (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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