| Autor: |
Chibvongodze, R, Nyirakanani, C, Ojwang, J.A., Mutuku, O.M., Ndung’u, J.R., Kyama, C.M. |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Zdroj: |
East African Medical Journal; Vol 94, No 10 (2017); 820-825 |
| ISSN: |
0012-835X |
| Popis: |
Background: HPV infection is a pre-requisite for the development of the majority (99.7%) of precancerous cervical lesions. Treatment of cervical precancerous lesions reduces the risk of invasive cervical cancer by 90%; however, treated women still have five times risk of invasive cancer compared to women who have always had a normal Pap smear, thus special follow-up measures are critical to reduce these risks.Objective: To determine the utility of co-testing by conventional Pap smear and HPV testing as a ‘test of cure’ in patients previously treated for cervical lesions by LEEP at KNH.Design: Cross sectional descriptive study.Setting: Kenyatta National Hospital and KAVI molecular laboratory.Subjects: Women on follow for cervical lesions post LEEP treatment.Results: Out of the 25 participants, 22(88%) had a report of NILM while 3(12%) had a report of ≥ASCUS). 16 (64%) were positive for HPV. HPV 56 was the commonest HPV subtype detected in 11 patients (41%). The Cohen’s Kappa correlation between Pap smear and HPV DNA test not statistically significant = 0.143, 95% CI: -0.17 to 0.46, p=0. 166.There was no statistically significant association between HIV status and pap smear findings post LEEP, X²=0.711, p=0.399Conclusions: Co-testing with HPV DNA testing and Pap smear is a useful approach to stratify women with no cytological abnormalities according to their risk of residual disease |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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