| Popis: |
Some quinoxaline derivatives 1-8 were synthesized and screened in vitro for their growth inhibitory activity against nine strains of Gram-positive and four strains of Gram-negative bacteria. Some of the compounds exhibited broad spectrum (in vitro) activity against the bacterial strains. One of the compounds, 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonyl azide (6), exhibited the highest activity with an MIC value of 7.8 ìgmL-1 against four Gram-positive bacterial strains.Keywords: Quinoxalinones, antibacterial, Gram-positive, Gram-negative. |
