| Autor: |
El-Samahy, Mona H, Adly, Amira AM, El-Gindi, Halla D, El-Ghaffar, Hend HA |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Zdroj: |
Egyptian Journal of Pediatric Allergy and Immunology (The); Vol 7, No 2 (2009) |
| ISSN: |
1687-1642 |
| Popis: |
Background: Antioxidant potential decreases while plasma lipid peroxidation products increase in type1 diabetes mellitus. The vascular endothelium is a major target of oxidative stress (OS). Reactive oxygen species signal events leading to impairment of endothelial function and promotion of leukocyte adhesion to the vascular endothelium.. Objective: To explore the relation between OS and adhesion molecules in type1 diabetes and correlate it with the state of metabolic control, disease duration and microvascular complications (MVCs). Design: Thirty-eight type 1 diabetics were included: 22 patients with disease duration less than 5 years and 16 patients with duration of 5 years or more. Thirty healthy age and sex matched subjects served as controls. They were assessed clinically. Laboratory investigations included, random blood sugar (RBS), glycated hemoglobin (HbA1c), fasting lipid profile and measurement of serum malondialdehyde (MDA) as a marker of lipid peroxidation and serum soluble P-selectin as a marker of endothelial/platelet activation. Results: Serum MDA and P-selectin were significantly elevated in type 1 diabetics compared to controls with the highest level in diabetics with disease duration of 5 years or more (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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