| Autor: |
Adejare, A.A., Oloyo, A.K., Anigbogu, C.N., Jaja, S.I. |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Nigerian Quarterly Journal of Hospital Medicine; Vol 27, No 2 (2017); 776-783 |
| ISSN: |
0189-2657 |
| Popis: |
Background: High blood pressure and myocardial oxygen demand have been shown to have positive correlation with the severity of cardiovascular disease. Although L-arginine is a known vasodilator, the role it plays in the modulation of physical parameters and myocardial oxygen demand in hypertension is not clearly understood.Objectives: This study sought to investigate the role of oral L-arginine supplementation in the modulation of physical parameters and myocardial oxygen demand in saltinduced hypertension.Methods: Forty-eight (48) weanling 6 weeks old Sprague- Dawley (SD) rats of body weights 50-60g were divided into 6 groups of 8 rats each. Group I was fed with normal rat chow containing 0.3% NaCl. Group II was fed with high salt diet containing 8% NaCl. Groups III and IV were fed normal and high salt diet respectively then supplemented with Larginine (100mg/kg/day) while groups V and VI were fed normal and high salt diet respectively then co-administered with both L-arginine and L-NAME (100mg/kg/day and 40mg/kg/day respectively). Blood pressure parameters were determined via left carotid artery cannulation. Rate pressure product (RPP) was calculated and used as an index of myocardial oxygen demand. Heart and kidney weights were also measured.Results: Salt-loading caused significant (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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