| Autor: |
Kouitcheu, MLB, Penlap, BV, Kouam, J, Ngadjui, BT, Fomum, ZT, Etoa, FX |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
African Journal of Biotechnology; Vol 5, No 11 (2006) |
| ISSN: |
1684-5315 |
| Popis: |
The ethyl acetate (EA) extract of the stem bark of Cylicodiscus gabunensis (CG) (Mimosaceae) was analysed for its anti-diarrhoeal activity. Like loperamide (3 mg/Kg body weight), a single oral dose of C.gabunensis ethyl acetate extract (CG-EA) (375, 750 mg/Kg body weight) produced a significant decrease in the severity of diarrhoea. To understand the mechanism of its anti-diarrhoeal activity, its effect was further evaluated on intestinal transit, castor oil induced intestinal fluid accumulation(enteropooling) and electrolyte concentration in the small intestinal fluid. CG-EA produced a decrease in intestinal transit (10.26-30.75%), and unlike atropine, it significantly inhibited castor oil induced enteropooling. However, it did not alter the electrolyte concentration in intestinal fluid as compared tocastor oil-treated rats |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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