Haemotological indices of Oryctolagus cuniculus (New Zealand Rabbit) experimentally infected with Trypanosoma brucei brucei treated with Diminazene Diaceturate (Sequzene) in Maiduguri, Borno State, Nigeria

Autor: Inuwa, A., Mbaya, A.W., Kokori, A.M., David, A.B.
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nigerian Journal of Parasitology; Vol 40, No 2 (2019); 296-302
ISSN: 1117-4145
Popis: This study was conducted to determine the haematological indices of experimentally inoculated O. cuniculus (New Zealand Rabbit) with T. b. brucei at a concentration of 1.5 x 106 then treated with Diminazine diaceturate (Sequzene) for twenty one (21) days. A total of thirty rabbits of both sexes were divided into six groups (A-F) of five (5) animals each. Group A were infected with T. b. brucei only but untreated, while Group B were uninfected, untreated control. Group C was infected with T. b. brucei and treated with Sequzene at 3.5 mg/kg, while Group D was infected and treated with the drug at 7.0 mg/kg body weight. Group E were uninfected with T. b. brucei and treated with Sequzene at 3.5 mg/kg and Group F was uninfected and treated at 7.0 mg/kg of the same drug. Physical symptoms were monitored daily and blood samples taken at seven days intervals then analysed for haematological parameters according to standard laboratory techniques. Physical signs observed include dullness, weakness, anorexia, weight loss, increased respiration, starry hairs and corneal opacity in the infected groups. The major haematological changes observed were anaemia characterized by a significant decline (p
Databáze: OpenAIRE