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This study was carried out to investigate the phytochemical constituents, analgesic and anti-inflammatory activity of methanol stem extract of Globimetula braunii. Preliminary phytochemical screening was done using standard protocols, median lethal dose (LD50) was determined by Lorke’s method. Analgesic and anti-inflammatory activities of extract were determined using acetic acid induced writhing and hot-plate model and the carrageenan-induced rat's paw edema model respectively at graded doses of 1000 mg/kg, 500 mg/kg and 250mg/kg. The phytochemical screening revealed the presence of flavonoids, steroid, triterpenes and saponins. Intraperitoneal median lethal dose of the extract was estimated to be greater than 5000 mg/kg bodyweight in mice. The extract exhibited highest percentage inhibition of writhing (99.24%) at a dose of 1000 mg/kg. However, the extract showed no central analgesic activity. Furthermore, the extract at lowest and highest dose (250 mg/kg and 1000 mg/kg) significantly (p |
