| Autor: |
Ebuehi, Osaretin Albert T., Solanke, Adebayo Solomon |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Nigerian Quarterly Journal of Hospital Medicine; Vol 24, No 3 (2014); 205-211 |
| ISSN: |
0189-2657 |
| Popis: |
Background: Cannabis sativa (marijuana) has been used recreationally and medicinally for several years; and there has been a steady increase in the consumption of cannabis among young people. 'Karole' is a therapeutical drug for the treatment of pain. Cannabis and analgesics have been reported to influence the central nervous system.Objectives: The study is to determine the effects of Cannabis sativa and 'Karole' on oxidative properties and brain serotonin in Wistar rats.Methods: Twenty four adult male rats ( 135.29 ± 7.26g), were randomly assigned into three treatment groups (n=6) and a control group (n=6). The treatments were administered orally and daily with marijuana extract (25mg/kg body weight), 'karole' (100 mg/kg body weight), and 10% ethanol for two weeks and five weeks. The rats in the control group received saline. The rats were allowed to feed ad libitum on rat chow. Three rats from each group were sacrificed at the end of second and fifth weeks of the experiment. Brain and liver homogenates were used to assay for activities of superoxide dismutase (SOD), catalase, levels of malondialdehyde (MDA) and reduced glutathione (GSH). The brain serotonin concentration was also determined.Results: There was a significant decrease (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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