Loss of maternal measles antibody in black South African infants in the first year of life implications for age of vaccination
| Autor: | Kiepiela, P, Coovadia, H. M., Loening, W.E.K., Coward, P., Abdool Karim, S.S. |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Zdroj: | South African Medical Journal; Vol 79, No 2 (1991); 145-148 |
| ISSN: | 2078-5135 0256-9574 |
| Popis: | In order to investigate the feasibility of measles vaccination before the age of 9 months the duration of passive immunity against measles was estimated by conducting a longitudinal study of measles antibody levels in 20 black neonates delivered at term. Measles serum antibody (lgG) was measured by enzyme-linked immunosorbent assay in the mother at childbirth and on consecutive samples taken from the infants from birth until 9 months of age. Protective measles antibody level was defined as > 200 mlU. Unprotective levels were found in 88% (95% confidence interval (Cl) 81 - 99%) of 6-month-old infants, while at 9 months all were susceptible. The mean antibody level was 192 mlU (Cl 104 - 348%) at 4 months; 34 mlU (Cl 15 - 73%) at 6 months and 13 mlU (Cl 6-24%) at 9 months of age. Our data support the recent World Health Organisation recommendation to immunise children in developing countries at 6 months with the 'high titre' Edmonston-Zagreb measles vaccine, since most infants in our study had lost passive immunity against measles by this age. |
| Databáze: | OpenAIRE |
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