Rapid eye movement sleep deprivation impairs hippocampus-dependent spatial memory: involvement of GABAergic receptors
| Autor: | Owoyele, B.V., Enaworu, I.I., Bayo-Olugbami, A.A., Owolabi, G.O. |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Journal of African Association of Physiological Sciences; Vol 6, No 1 (2018); 38-45 |
| ISSN: | 2315-9987 2449-108X |
| Popis: | Background: This study examined the effect of rapid eye movement (REM) sleep deprivation on spatial memory in Wistar rats and the role of GABAergic receptors.Methods: A total of thirty-six age matched male Wistar rats weighing 170-200g were grouped into six (A-F) of six animals each. Group A served as control, Group B was sleep deprived, rats in groups C-F in addition to being sleep deprived for 72 hrs, received Diazepam (1mg/kg) (C), Baclofen (5mg/kg) (D), Phaclofen (1mg/kg) (E), Bicuculline (2mg/kg) (F) respectively. Spatial memory was accessed using Morris water maize (MWM) while motor performance (MP) and working memory were accessed using Y-Maze. Some serum biochemical parameters were also assessed.Results: These showed that spatial memory was decreased in the sleep deprived group compared with control (p |
| Databáze: | OpenAIRE |
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