Pro-ulcerogenic activity of sodium arsenite in the gastric mucosa of male wistar rats
| Autor: | Adebayo-Gege, G.I., Salami, A.T., Odukanmi, A.O., Omotosho, I.O., Olaleye, S.B. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Journal of African Association of Physiological Sciences; Vol 6, No 2 (2018); 95-103 |
| ISSN: | 2315-9987 2449-108X |
| Popis: | Background: The gastrointestinal tract is constantly exposed to various protective and aggressive factors from food and the environment. Recent studies have shown that environmental factors, including heavy metal exposure and diet may alter gastrointestinal mucosal integrity. Arsenic (extensively available in the form of oxides or sulfides or as a salt of iron, sodium, calcium, copper, etc) is a major contaminant of soil, air as well as various water sources used for human and industrial activities, making it a huge public health burden. The present study was designed to characterize gastrointestinal alterations induced by sodium arsenite (SA) exposure.Methods: Sixty-four male Wistar rats were divided into four groups (n = 16) in two separate studies. Groups I and 2 received distilled water and indomethacin (40mg/kg, p.o) respectively while groups 3 and 4 animals received 5mg/kg and 10mg/kg SA respectively for two weeks prior to administration of indomethacin. In the first study, gastric acid secretion (GAS) was studied using the continuous perfusion technique. In the second study, animals were sacrificed after indomethacin administration. Ulcer was assessed based on macroscopic appearance of the stomach using an ulcer score scale. Each excised stomach was thoroughly cleaned and small sections were taken for histological analysis. Data were analysed using one-way ANOVA and differences considered significant at p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|