Ameliorative Effects of Adansonia Digitata Leaf Extract on Carbon Tetrachloride (CCL4) Induced Testicular Toxicity in Adult Male Wistar Rats
| Autor: | Oyetunji, OA, Babatunde, IR, Chia, SL, Abraham, OA, Adewale, FB, Eweoya, O, Williams, FE |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Anatomy Journal of Africa; Vol 4, No 1 (2015); 481 – 487 |
| ISSN: | 2226-6054 2305-9478 |
| Popis: | Adansonia digitata is locally consumed as food in Nigeria. In the present study, the ameliorative effect of the aqueous leaf extract of Adansonia digitata (AeAD) was evaluated in carbon tetrachloride (CCl4) – induced testicular toxicity in Wistar rats. To evaluate the effect of AeAD in CCl4 induced testicular toxicity, 20 adult male Wistar rats were equally divided into 4 groups (n=5). Group A animals received 1 ml olive oil per os (p.o) for two weeks, Group B animals received 2.5 ml/kg CCl4 (50% in olive oil, p.o) for two days, Group C animals received 500 ml/kg AeAD (p.o) for two weeks while Group D animals received 2.5 ml/kg CCl4 (50% in olive oil, p.o) for two days followed by 500 ml/kg AeAD (p.o) for two weeks. The ameliorative effects of AeAD were observed on reproductive hormonal parameters, activity of an antioxidant enzyme and cyto-architecture of the testis. Carbon tetrachloride treatment significantly (P |
| Databáze: | OpenAIRE |
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