| Autor: |
Shalaby, SA, Al-Edressi, HM, El-Tarhouny, SA, EL-Bab, MF, Zolaly, MA |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Arab Journal of Nephrology and Transplantation; Vol 6, No 2 (2013); 83-88 |
| ISSN: |
1858-554X |
| Popis: |
Introduction: In view of the conflicting evidence of helper T cell type 1 (Th1) or type 2 (Th2) pattern of cytokine synthesis in steroid sensitive nephrotic syndrome (SSNS), this study aimed to assess type-1/type-2 cytokines level in different stages of SSNS and to evaluate the role of IL-18.Methods: We prospectively studied thirty children with SSNS, aged 2–12 years. The children were evaluated in the active stage before treatment initiation and re-evaluated again during remission while still on steroid treatment. A subgroup of children (21/30) was also evaluated during remission after steroid withdrawal. The control group included 30 healthy age- and sex-matched controls. Serum levels of IL-2, IFN-ã, ÉL-4, IL-13 and IL-18 were measured by ELISA.Results: IL-2 levels were not significantly different between children in different stages of SSNS and controls (p > 0.05). Levels of IL-4, IL-13 and IL-18 were significantly higher during the active stage of SSNS compared to remission and controls (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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