Utilisation of prophylactic anti-D to prevent Rhesus haemolytic disease of the foetus or newborn in Zimbabwe

Autor: Mandisodza, A, Sithole, S, Maramba, A, Chikwasha, V, Mberi, E, Marques, D, Maboreke, T
Jazyk: angličtina
Rok vydání: 2019
Zdroj: Central African Journal of Medicine; Vol 64, No 4-6 (2018); 32-36
ISSN: 0008-9176
Popis: Objective: To assess the uptake of Prophylactic Anti-D (RhoGam) in Zimbabwe to prevent Haemolytic Disease of the Foetus or Newborn (HDFN) due to Rhesus D immunization of pregnant mothers who were Rhesus D negative and had not been previously immunized.Design: A five year retrospective study.Setting: National Blood Service Zimbabwe (NBSZ).Subjects: Nine hundred and thirty six Rhesus D negative women.Results: Seventy-seven percent (77%) of Rhesus D negative women were eligible for RhoGam. The remainder (23%) was not eligible due to either prior immunization by Rhesus D positive infants during unmonitored previous pregnancy or previous transfusion with Rhesus D positive blood or had given birth to Rhesus D negative infants. The average uptake of RhoGam was only 19.5% over the five years. The apparent increase in uptake in years 1 and 3 was not statistically significant (p = 0.5543). There was a gradual decline in the uptake of RhoGam from 31.8% in the first year of the study to 9.3% in the fifth year. The decline was statistically significant (p
Databáze: OpenAIRE