| Popis: |
Hyperhomocysteinemia has been described as a risk factor for infertility and adverse pregnancy outcomes such as recurrent/early pregnancy loss, pre-eclampsia and intrauterine growth restriction. Although Nigeria has a high prevalence of infertility, the contribution of homocysteine to female infertility is yet to be studied. This study aim to find possible relationship between elevated plasma homocysteine level and infertility. This descriptive cross-sectional study was carried out among eligible infertile and fertile women seeking care at the Lagos University Teaching Hospital. The subjects were 100 infertile women randomly selected from the fertility clinic, and the controls were 50 fertile women that have given birth in the last one year. Fasting plasma levels of homocysteine were estimated using enzyme immunoassay technique, while anticoagulated whole blood sample was used to evaluate haematological parameters (Hb, WBC, MCV, MCH, MCHC, RDW %), using the HMX haematology autoanalyser by Beckman Coulter. Statistical analysis was performed using the Chi-square and simple logistic regression model for associations and Student t-test for mean differences. Statistical significance was set at p-value |
