| Autor: |
Mugendi, GA, Nyamu, DG, Okalebo, FA, Nyamweya, NN, Ndwiga, S, Mwangi, M |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Zdroj: |
East African Medical Journal; Vol 91, No 4 (2014); 125-132 |
| ISSN: |
0012-835X |
| Popis: |
Objective: The objective of this study was to compare renal function in diabetic hypertensive chronic kidney disease patients receiving enalapril or losartan.Design: This was a retrospective analytic cohort study.Setting: Kenyatta National Hospital, Nairobi, Kenya.Subjects: Two hundred adult patients with hypertension and diabetic nephropathy.Interventions: One hundred and sixteen participants received an enalapril regimen while 84 were on a losartan regimen.Main outcome measures: time to doubling of serum creatinine and changes in the levels of proteinuria.Results: There was a higher risk of doubling of serum creatinine with losartan (Adjusted HR=1.572; [95% CI:1.015-2.434]; p=0.043) than enalapril. There was a significant difference in time to doubling between the two arms – losartan 18 months, enalapril 36 month (p=0.046). The changes in the levels of proteinuria between the two arms were not statistically significant for most of the follow up period except at the 15thmonth from treatment initiation (p=0.05).Conclusions: Enalapril was found to be more reno-protective compared to losartan. Where feasible, we suggest local use of enalapril as opposed to losartan for diabetic hypertensive chronic kidney disease patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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