| Popis: |
The antiplasmodial activity of extracts and fractions of Mangifera indica was carried out in a 4-day suppressive and 7-day curative test procedure. Six groups of animals were administered with crude extracts of 80% methanol, dichloromethane, and fractions of petroleum acetate, chloroform, ethyl acetate and n-butanol respectively while the control group received 0.2ml of normal saline and the positive control was given 5mg/kg chloroquine phosphate. The animals administered with dichloromethane extract produced the highest survival time (21.50€ 1.19) days and significantly different (P0.05). A dose of 200mg/kg/day of ethyl acetate fraction of M. indica applied orally, reduced parasitaemia by >50%. The extracts and fractions of M. indica showed significance difference (P50% reduction in Plasmodium berghei parasitaemia obtained from the extracts and fractions was not unconnected to the leaves of M. indica.Keywords: Antiplasmodial, Mangifera indica, extracts, fractions, Plasmodium berghei |
