| Autor: |
Shalaby, SA, El Idrissy, HM, Safar, RA, Hussein, ST |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Arab Journal of Nephrology and Transplantation; Vol 5, No 1 (2012); 13-17 |
| ISSN: |
1858-554X |
| Popis: |
Introduction: Little is known about the relationships between the T lymphocytes (CD3+) expression of glucocorticoid receptors (GCR) and the response to glucocorticoid treatment in children with idiopathic nephrotic syndrome (NS). The aim of the current study is to determine whether steroid responsiveness is dependent on the amount of T lymphocytes GCR expressionMethods: We studied 60 children with idiopathic NS in the age group from 2-10 years. According to the response to steroids we classified our patients into early responders (ER; n=46) and late responders (LR; n=14). Sixty age and gender matched healthy children represented the control group. The clinical and laboratory findings at baseline and GCR expression by T lymphocytes (CD3+) as determined by flow cytometry were compared between the three groups.Results: The T lymphocytes (CD3+) expression of GCR was significantly lower in the LR than that in the control group (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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