| Autor: |
Mutai, C., Mibei, E. K., Etabalé, J. M., Oyieko, W., Magak, G. N. |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Zdroj: |
East African Medical Journal; Vol. 99 No. 6 (2022); 4925-4933 |
| ISSN: |
0012-835X |
| Popis: |
Background: The potential roles of inflammatory makers in prostate cancer are subjects of intense examination and Interleukin-6 receptor (IL-6R) is key in these processes. Expression of interleukin-6 Receptor (IL-6R) has not been evaluated as a prognostic biomarker in grading of prostate cancer (Pca) in our population, yet inflammation is not uncommon. The current study therefore evaluated their expression in prostatic acinar adeno-carcinoma (PAA) patients of different Gleason grades. Objective: To evaluate the expression of IL-6R in prostatic acinar adeno-carcinoma patients of different Gleason Grades Design: A retrospective study. Setting: The Kisumu Specialist Hospital (KSH) in Kisumu County, Western Kenya. Materials and methods: Eighty (80) formalin-fixed prostate cancer Gleason graded biopsy specimens obtained at the KSH between 1st January 2017 and 30th June 2019. Kruskal-Wallis, one way ANOVA and Spearman’s correlation coefficient test were used to determine the correlation of tissue IL-6R expression and the clinico-pathological parameters Results: Immune-reactivity score analysis of 80 patient’s samples showed high IL-6R expressions (37:46.3%), moderate IL-6R expression (15:18.8%) and low IL-6R expression (28:35%). A significant positive correlation was observed between IL-6R expression and both GS (r=0.470, p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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