| Autor: |
Knežević, Anamarija, Landek, Goran, Vinković, Vladimir |
| Přispěvatelé: |
Tomašić, Vesna, Maduna Valkaj, Karolina |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
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| Popis: |
Based on our prior work in Laboratory for Stereoselective Catalysis and Biocatalysis at Ruđer Bošković Institute in the field of chiral recognition of Pirkle-type chiral stationary phases (CSPs) [1-4] we designed and prepared the new sort of CSPs. To improve the chiral discrimination performance these new Pirkle-type CSPs have lacking some of non-stereoselective adsorption sites. Chiral selector of CSP I, an N-(1-arylpropyl)-3, 5-dinitrobenzamide unit, possesses all the characteristics of a good selector – it is rigid and contains a strong pi-accepting 3, 5-dinitrobenzoyl (DNB), and a strong pi-donating aromatic group (Ar). The necessary compounds were prepared from enantiomerically pure allyl-arylamines (I) obtained by enzymatic resolution or preparative chiral chromatography of racemic amines. Previous synthetic step was [3, 3]-sigmatropic rearrangement of acyclic imidates that gives racemic amines. Imidates are easily prepared from corresponding alcohols which are usually commercially unavailable and must be synthesized from commercial aryl aldehydes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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