| Autor: |
Ivić, Ivan, Čavka, Ana, Grizelj, Ivana, Mihaljević, Zrinka, Koller, Akos, Drenjančević, Ines |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Popis: |
Objective: Zinc (Zn) and selenium (Se) are important part of antioxidant enzymes which protects against reactive oxygen species (ROS). It has been suggested that altered levels of Zn and/or Se in liver and kidney can contribute or correlate to the impaired antioxidant defense leading to endothelial dysfunction. However, there are few data available regarding the effects of dietary Zn and Se on the vasomotor responses of vessels. Thus we hypothesized that changing dietary content of Zn and Se will alter vasomotor responses of isolated rat carotid arteries. Methods: Male Sprague Dawley rats (n=33) were fed with 4 types of rat chows for 10 weeks: a) low Zn-low Se group (n=8) (normal chow) b) high Zn-high Se (N=5) ; c) high Zn low-Se group (N=10) ; d) low Zn-high Se group (N=10). Carotid arteries (CA) were isolated and their isometric tensions were measured by DMT wire Myograph system. Responses of noradrenaline pre- contracted CA to ACh (10- 9-10-5 M) in the absence or presence of L-NAME. Statistical significance was set at P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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