| Autor: |
Pašalić, Daria, Ferenčak, Goran, Gršković, Branka, Cheng, Suzanne, Fijal, Bonnie, Šesto, Mihajlo, Skodlar, Jasna, Stavljenić Rukavina, Ana |
| Jazyk: |
angličtina |
| Rok vydání: |
2003 |
| Předmět: |
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| Popis: |
We investigated the relationship between lipoprotein lipase (LPL) gene polymorphisms (-93 T/G, D9N, N291S, and S447X), coronary artery disease (CAD) and lipid traits. We examined Croatian patients with (n=497) and without (n=200) angiographically confirmed CAD. The N291S polymorphism was significantly associated with CAD (OR: 0.36 ; p: 0.048). HLD2-cholesterol and apolipoprotein A I levels were significantly higher in non-carriers of the -93T/G and D9N polymorphisms in the CAD group (p: 0.017 and 0.028, respectively). The N291S genetic variant did not show any significant difference between carriers and non-carriers in the both groups studied for any of the lipids. Lower triglyceride and higher HDL2-cholesterol levels in the control group were associated with carriers of the S447X mutation (p: 0.043 and 0.056, respectively). We conclude that modification in lipoprotein lipase gene might influence lipid levels, and confer risk for CAD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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