| Autor: |
Knežević-Ćuća, Jadranka, Stansberry, KB, Johnston, G, Zhang, J, Keller ET, Vinik AI. |
| Jazyk: |
angličtina |
| Rok vydání: |
2000 |
| Předmět: |
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| Popis: |
Interleukin 6 (IL-6) plays a role in physiological and pathophysiological processes in neuronal cells. We studied whether IL-6 plays a role in neuroblastoma cells in culture. These studies demonstrate that N1E-115 cells constitutively express IL-6 but not IL-6R. Exogenous IL-6 stimulated neuronal proliferation in a dose-dependent manner. Under serum-free conditions soluble IL-6 receptors (sIL-6R) alone or in combination with IL-6 exerted significant proliferative effects, while IL-6 alone failed to promote cell proliferation. Neutralizing anti-IL-6 antibody caused a 30-40% reduction in IL-6 mediated proliferation. Our results suggest the importance of IL-6/sIL-6R for proliferation and survival of N1E-115 adrenergic neuroblastoma cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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