| Autor: |
Herak, Jure, Vinković, Mladen, Mandić, Zorica, Lukić, Irena, Kovačević Miće |
| Jazyk: |
angličtina |
| Rok vydání: |
1993 |
| Předmět: |
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| Popis: |
The enantiomerically pure substituted 2-azacephams 5 were synthesized by intramolecular cyclization of sulfinamides 4. Their absolute configurations were confirmed by X-ray crystal structure determination of (5R, 6R)-4-benzyl-2-isopropylidene-5-oxo-5-thia-1, 4-diazabicyclo(4.2.0)octane-3, 8-dione 5a. Nucleophilic opening of 2-azacephams by methanol occured rapidly to give sulfinates 8 with excellent regio and stereo selectivity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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