| Popis: |
Foods for special medical purposes (FSMPs) are unique therapeutic products formulated for the specific dietary management of disease-related conditions or specific medical disorders, for which distinctive nutritional requirements, based on recognized evidence-based scientific principles, are established. The human microbiome is composed of microbes that have a tremendous potential to impact our physiology, both in health and in disease. Since high-fiber diet impacts the entire gut microbe community and improves blood- glucose regulation, they can be used as FSMPs, in which they pose a beneficial effect in maintaining the gastrointestinal health.Therefore the aim of this research was to establish the lactogenic and bifidogenic effects of three different innovative fibers (K1, D1, D2), in order to develop innovative formulations of foods for diabetic medical purposes, using a diabetic mouse model. Standard diabetic fiber mixures and food without added fibers, were used as controls. All tested innovative dietary fibers showed in vivo lactogenic and in vitro bifidogenic and lactogenic effect, where the best effects were achieved with the addition of D2 innovative fiber mixture, respectively. Additionally, after feeding the mice, all innovative dietary fibers showed a positive impact on the growth of Lactococcus spp., with the best results upon the addition of D2 innovative fiber mixture. Innovative fiber mixture (D1) reduced the number of L. monocytogenes to undetectable cell count level, significantly decreased the number of S. aureus and Salmonella spp., while innovative fiber mixture (D2) significantly decreased the number of L. monocytogenes and S. aureus, in diabetic mice faeces samples in vivo. The reduction of L. monocytogenes was also achieved with innovative (K1) and standard (K0) fiber mixtures, to undetectable cell count level. Finally, innovative fiber mixtures (D1 and D2), along with the standard fiber mixtures (K0) showed the impact on the incresement of the total bacteria number in vivo. In conclusion, two innovative mixtures of dietary fibers, D1 and D2, can be used as nutritional supplementation for foods for diabetic medical purposes. |
