| Popis: |
1194 chordocenteses were analyzed cytogenetically in a period of 22 years, using cytogenetical GTG-banding method. Indications for chordocenteses were late weeks of pregnancy (ultrasound markers, parents carrieres of reciprocal translocation, age, … ) and amniocenteses From total number of 1194 chordocenteses, 88 (7, 37 %) were karyotypically determined as pathologic: 63 (71, 5 %) numerical aberrations and 25 (28, 4 %) structural aberrations. The most frequent numerical aberrations were trisomie of chromosome 21 (21/63 ; 33.3 %) and trisomie of chromosome 18 (20/63 ; 31.7 %). Pathology in amniocenteses were confirmed with almost 100 % accuracy with chordocenteses. Considering other indications for chordocentesis, most pathologic karyotypes were confirmed at ultrasound markers indication (45/60 ; 75%). |
