| Autor: |
Rider, Patrick, Perić Kačarević, Željka, Elad, Akiva, Rothamel, David, Sauer, Gerrit, Bornert Fabien, Windisch, Peter, Hangyási, Dávid, Molnar, Balint, Hesse, Berhard, Assad, Michael, Witte, Frank, Rogge, Svenja, Tadić, Dražen |
| Přispěvatelé: |
Mantovani, D, Witte, F, Zheng, Y, Staiger, M |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Popis: |
INTRODUCTION: To overcome the limitations of collagen membranes, which are most used membranes for guided bone regeneration (GBR), a synthetic magnesium membranes has been developed as alternatives. METHODS: Eighteen Beagle dogs were divided into three cohorts of six animals each at different time points (1 week, 8 weeks, 16 weeks), and two animals were assigned to a 52-week cohort. Experimental bone defects were filled with bovine xenograft and covered with either magnesium membrane or collagen membrane. The health status of the animals was regularly monitored and recorded. Following sacrifice, the hemimandibles were prepared for micro-CT (μ-CT) analysis. The following outcomes were observed - the new bone volume/total defect volume (BV/TV), soft tissue volume, void volume and residual magnesium metal and histological evaluation. The surface area and volume of the magnesium metal were also determined. RESULTS: The μ-CT analysis and histology evaluation showed that the greatest degradation of the magnesium membranes occurred between 1 and 8 weeks and continued until week 16, when only one membrane had visible remnants. Complete degradation of all the magnesium membranes had occurred at a time point of 52 weeks. DISCUSSION & CONCLUSIONS: The in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen membrane. Overall, the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
