| Autor: |
Sakan, Sanja, Kralik, Kristina, Mihelčić, Antonija, Hleb, Sonja, Blagaj, Vanja, Čučković, Marcela, Dobrović, Karolina, Mikecin, Verica, Kristović, Darko, Desnica, Marina, Sojčić, Nataša, Bradić, Nikola, Šribar, Andrej, Šafarić Oremuš, Zrinka, Peršec, Jasminka |
| Přispěvatelé: |
Peršec, Jasminka |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Popis: |
Objectives: During the COVID-19 pandemics we have seen in critically ill COVID-19 patients treated in the intensive care unit the parallel outbreak of multidrug resistant Gram-negative bacteria bloodstream infec tions, mainly Acinetobacter baumannii and Klebsiella pneumoniae. Methods: We conducted a retrospective cohort single-center study. The aim was to investigate the incidence, etiology and impact of intensive care unit bloodstream infections in COVID-19 patients admitted to the COVID-19 intensive care unit with a known burden of multidrug resistance and to evaluate the possibility that inflammatory parameters levels measured at two dif ferent time points of treatment can early predict multidrug resistant Gram-negative bacteria bloodstream infec tions and enable timely beginning of bacterial targeted antimicrobial therapy. Results: Our study confirmed that procalcitonin values of 2, 46 mcg/L and neutrophil/lymphocyte ratio of 28, 9 could be a reliable indicators for high risk stratification of multidrug resistant Gram- negative bacterial infection origin in critically ill COVID-19 patients (Mann Whitney U test, P=0, 02). Conclusion: Monitoring dynamic shift of inflammatory parameters in critically ill COVID-19 patients could reliably help clinician to recognize the multidrug resistant Gram-negative bacteria bloodstream infections and start with the antimicrobial therapy in a timely manner |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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