| Autor: |
Mikulandra, Ivana, Facković, Matea, Lulić, Ana- Marija, Habinovec, Iva, Benčić, Noelle, Bukvić, Mirjana, Grgičević, Ivan, Jednačak, Tomislav, Cindrić, Marina, Zangger, Klaus, Novak, Predrag |
| Přispěvatelé: |
Galić, Nives, Rogošić, Marko |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Popis: |
Macrolide antibiotics, such as azithromycin, have been widely prescribed for the treatment of respiratory tract infections owing to their high efficacy and safety.[1] Azithromycin belongs to an azalide subclass of 15-membered macrolide antibiotics. Emerging multi-drug resistant microbial pathogens present today a serious and challenging global problem which demands novel and more effective antimicrobial agents to be discovered. Thiosemicarbazones and some of their metal complexes have been shown to possess anti- infective, anti-inflammatory and antitumor activities. Some thiosemicarbazones have proven very useful to treat infections, such as the new antibiotics perchlozone and thiacetazone, which are good new agents against tuberculosis.[2] Our earlier experiments which included synthesis and biological and structural characterization of some macrolide conjugates showed that those hybrid compounds exhibited good activity against some resistant bacterial strains.[3-4] Here, we present synthesis and characterization of novel macrolide conjugates, the macrozones by linking azithromycin and some selected thiosemicarbazones. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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