| Autor: |
Fučić, Aleksandra, Znaor, Ariana, Jazbec, Ana-marija, Sedlar, Miljenko |
| Přispěvatelé: |
GarajVrhovac, Verica, Kopjar, Nevenka, Miljanić, saveta |
| Jazyk: |
angličtina |
| Rok vydání: |
2005 |
| Předmět: |
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| Popis: |
The last few years have shown that cytogenetic biomarkers do predict increased cancer risk. The most frequently used biomarkers in genetic toxicology are chromosome aberations assay(CA) and micronucleus assay (MN) assay. Fluorescent in situ hybridization (FISH)in turn, enables, analysis of translocation as a stable genome damage. With technological development, working environment has become associated with complex exposure to ionizing and non-ionizing radiation and chemical agents.A follow-up of 1200 subjects occupationally exposed to ionizing radiation and chemical agents using CA and MN showed that the highest deviations from control values were detected in complex exposure to ionizing radiation and ultrasound or to radioisotopes in medicine and to ionizing radiation in specific jobs in nuclear plants. FISH used in a group of subjects exposed to gamma radiation and ultrasound showed that translocation frequency could rise even when when CA frequency is withincontrol values. This example shows that health risk is present even when results obtained by routine methods for the last few decades do not deviate from control values and that a decrease in permissible doese does not protect from accumulated genome damage during employment under different conditions. As biological effects of complex exposure are not possible to minotor by physical measurements, cytogenetic biomarkers are the only relible tools to evaluate genome damge and significant parameters in regulating health surveillance of exposed subjects. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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