| Autor: |
Somborac Bačura, Anita, Rumora, Lada, Meštrić, Ines, Vukelić, Martina, Matokanović, Mirela, Pancirov, Dolores, Popović-Grle, Sanja, Čepelak, Ivana, Žanić Grubišić, Tihana |
| Přispěvatelé: |
Dumić, Jerka, Kovarik, Zrinka, Varljen, Jadranka |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Popis: |
Matrix metalloproteinase-9 (MMP-9) is a zinc-dependent endopeptidase capable of cleaving several constituents of extracellular matrix, such as collagen, gelatin, elastin, etc. Therefore, MPP-9 plays an important physiological role in lung extracellular matrix remodeling and repair. In the lungs of patients with chronic obstructive pulmonary disease (COPD) increased degradation of extracellular matrix and airway remodeling are present. Several studies showed increased levels of MMP-9 in alveolar macrophages, neutrophils and sputum of COPD patients. In this study, we measured MMP-9 concentration in plasma samples of COPD patients using a commercially available ELISA kit. We found statistically significant increase in the median value of MMP-9 concentration in COPD patients (204.1 (115.7-351.2) ng/mL ; N=59) comparing to healthy controls (70.2 (52.4-104.9) ng/mL ; N=21), P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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