| Autor: |
Rusić-Pavletić, Jasna, Brajša, Karmen, Glojnarić, Ines, Čulić, Ognjen, Dominis-Kramarić, Miroslava, Marković, Darko, Bencetić, Vlatka, Šunjić, Ivan, Eraković, Vesna, Danhoff Meinrat, Parnham Michael |
| Jazyk: |
angličtina |
| Rok vydání: |
2000 |
| Předmět: |
|
| Popis: |
Macrolides have been reported to reduce phagocytosis, neutrophil chemotaxis, and the relise of proinflammatory cytokines (Il-1 and TNFa). An animal model was designet to evaluate the effect of erythromycin (Ery) in rats upon LPS induced inflammation. Cytokines, IL-6 and IFN gamma and acute phase proteins, CRP, alpha2 macroglobulin and albumins were chosen as markers and monitored 48 hours. A 3.2 mg/kg dose of LPS resulted in pronouced inflammatory symptoms and was used in the following experiments. Animals treated with Ery showed 2-fold lower concentrations of IL-6 and IFN gamma. Albumins, CRP and alpha 2 macroglobuline were decreased. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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