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Introduction and Aims: Retrospective cohort presents clinical and histopathological data of patients with pauci immune rapidly progressive glomerulonephritis (RPGN), diagnosed and treated in our hospital over 15 year period. (2000-2015.) Methods: 75 of 1517 patients, enrolled in our renal biopsy registry, with pauci immune RPGN were analysed. Based on patohistological and clinical data they were diagnosed with one of the small-vessel ANCA associated vasculitis: microscopic polyangiitis (MPA) 45, 3%, granulomatosis with polyangiitis (GPA) 22, 7%, eosinophilic granulomatosis with polyangiitis (EGPA) 4% or renal limited vasculitis (RLV) 28%. We analysed epidemiological data, blood pressure, extrarenal disease manifestations (respiratory, skin, general simptoms), serum creatinine (Sc), creatinine clearance (CrCl), 24h proteinuria, C-reactive protein (CRP), antineutrophilic cytoplasmic antibiodies (PR3 and MPO - ANCA), treatment, plasmapheresis (PF) and need for renal replacement therapy (RRT). Birmingham vasculitis activity score was calculated. Median value and interquartile(IQ) range of continuing variables were compared using Kruskal-Wallis and Mann-Whitney U test. Category variables were compared using χ2-test and Fisher Exact test. Analysis was performed using SPSS statistical software version 17.0. (p |
