| Autor: |
O. P. Nyssen, D. Bordin, B. Tepes, A. Pérez-Aisa, D. Vaira, M. Caldas, L. Bujanda, M. Castro- Fernandez, F. Frode Lerang, M. Leja, L. Rodrigo, T. Rokkas, L. Kupcinskas, J. Pérez-Lasala, L. Jonaitis, O. Shvets, A. Gasbarrini, H. Simsek, A. T. R Axon, G. M. Buzás, J. Machado, Y. Niv, L. Boyanova, A. Goldis, V. Lamy, Ante Tonkić, K. Przytulski, C. Beglinger, M. Venerito, P. Bytzer, L. G. Capelle, T. Milosavljevic, V. Milivojevic, L. Veijola, J. Molina-Infante, L. Vologzhanina, G. Fadeenko, I. Ariño, G. Fiorini, A. Garre, J. Garrido, C. F. Pérez, F. Heluwaert, I. Puig, F. Mégraud, C. O'Morain, J. P. Gisbert |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
Background: The best approach for Helicobacter pylori management remains unclear. An audit process is essential to ensure clinical practice is aligned with best standards of care. Design: International multicentre prospective non- interventional registry starting in 2013 aimed to evaluate the decisions and outcomes in H. pylori management by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap up to April 2020. Variables included: demographics, previous eradication at-tempts, prescribed treatment, adverse events, and outcomes. Modified intention-to-treat (mITT) and per- protocol (PP) analyses were performed and data were subject to quality review to ensure information reliability. Results: In total 36, 319 patients from 29 European countries were evaluated and 24, 882 (70%) first-line empirical H. pylori treatments were included for analysis. Triple therapy with amoxicillin and clarithromycin was most commonly prescribed (40%), followed by concomitant treatment (19%) and bismuth quadruple (Pylera®) (10%) achieving 83%, 91% and 95% mITT eradication rate, respectively. Over 90% effectiveness was obtained only with 10 and 14-day bismuth quadruple or 14-day concomitant treatment. Longer treatment duration, higher acid inhibition and compliance were associated with higher eradication rates. Conclusions: Management of H. pylori infection by European gastroenterologists is heterogeneous. Only quadruple therapies lasting at least 10 days are able to achieve over 90% eradication rates. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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